You can replace the contents of Series entirely but keep all references in place in your charts and tables.
A common application for this is when you have a spreadsheet of data that you routinely copy and paste into dataZoa.
After you have uploaded the spreadsheet the first time, just use the Workbench to Export the series to a file. The file header will have a row of series keys you can then add to your spreadsheet to use from then on.
Like this... Original: With Keys:
> Foreign Exchange